Quantitative susceptibility mapping of hippocampal iron relates to pattern separation and completion in older adults at risk for Alzheimer's

Journal article

Jing Zhou, Alfie Wearn, Julia Huck, Giulia Baracchini, J. Tremblay-Mercier, Judes Poirier, Sylvia Villeneuve, C. Tardif, Ana M. Daugherty, Claudine Gauthier, Gary Turner, R. Spreng
ISMRM Annual Meeting

Semantic Scholar DOI

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APA Click to copy
Zhou, J., Wearn, A., Huck, J., Baracchini, G., Tremblay-Mercier, J., Poirier, J., … Spreng, R. Quantitative susceptibility mapping of hippocampal iron relates to pattern separation and completion in older adults at risk for Alzheimer's. ISMRM Annual Meeting.

Chicago/Turabian Click to copy
Zhou, Jing, Alfie Wearn, Julia Huck, Giulia Baracchini, J. Tremblay-Mercier, Judes Poirier, Sylvia Villeneuve, et al. “Quantitative Susceptibility Mapping of Hippocampal Iron Relates to Pattern Separation and Completion in Older Adults at Risk for Alzheimer's.” ISMRM Annual Meeting (n.d.).

MLA Click to copy
Zhou, Jing, et al. “Quantitative Susceptibility Mapping of Hippocampal Iron Relates to Pattern Separation and Completion in Older Adults at Risk for Alzheimer's.” ISMRM Annual Meeting.

BibTeX Click to copy

@article{jing-a,
  title = {Quantitative susceptibility mapping of hippocampal iron relates to pattern separation and completion in older adults at risk for Alzheimer's},
  journal = {ISMRM Annual Meeting},
  author = {Zhou, Jing and Wearn, Alfie and Huck, Julia and Baracchini, Giulia and Tremblay-Mercier, J. and Poirier, Judes and Villeneuve, Sylvia and Tardif, C. and Daugherty, Ana M. and Gauthier, Claudine and Turner, Gary and Spreng, R.}
}

Abstract

Quantitative susceptibility mapping (QSM) was used to evaluate hippocampal iron in a cohort of healthy older individuals at elevated risk for Alzheimer’s disease (AD), and related to pattern separation and pattern completion memory performance. Our results demonstrated that elevated brain iron content in the hippocampus is strongly associated with lower performance on behavioral tests specific to memory function, ie lower pattern separation scores and higher pattern completion scores. Our findings suggest that hippocampal iron deposition may be a pathological mechanism resulting in poorer mnemonic discrimination in later life