Journal article
Alfie Wearn, Stéfanie Tremblay, Ilana Leppert, Giulia Baracchini, Colleen Hughes, Gary Turner, Claudine Gauthier, Christine Tardif, R. N. Spreng
ISMRM Annual Meeting
ISMRM Annual Meeting
Semantic Scholar
DOI
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APA
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Wearn, A., Tremblay, S., Leppert, I., Baracchini, G., Hughes, C., Turner, G., … Spreng, R. N. In vivo microstructural mapping of the hippocampus in older adults with familial risk for Alzheimer’s disease. ISMRM Annual Meeting.
Chicago/Turabian
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Wearn, Alfie, Stéfanie Tremblay, Ilana Leppert, Giulia Baracchini, Colleen Hughes, Gary Turner, Claudine Gauthier, Christine Tardif, and R. N. Spreng. “In Vivo Microstructural Mapping of the Hippocampus in Older Adults with Familial Risk for Alzheimer’s Disease.” ISMRM Annual Meeting (n.d.).
MLA
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Wearn, Alfie, et al. “In Vivo Microstructural Mapping of the Hippocampus in Older Adults with Familial Risk for Alzheimer’s Disease.” ISMRM Annual Meeting.
BibTeX Click to copy
@article{alfie-a,
title = {In vivo microstructural mapping of the hippocampus in older adults with familial risk for Alzheimer’s disease},
journal = {ISMRM Annual Meeting},
author = {Wearn, Alfie and Tremblay, Stéfanie and Leppert, Ilana and Baracchini, Giulia and Hughes, Colleen and Turner, Gary and Gauthier, Claudine and Tardif, Christine and Spreng, R. N.}
}
Abstract
Motivation: Understanding prodromal Alzheimer’s disease is essential for treatment development. Hippocampal volume loss indicates significant atrophy and may occur too late to slow disease progression. Goal(s): We aimed to precisely map spatial variation in hippocampal microstructure in vivo using quantitative MRI in prodromal AD. Approach: We use multiparametric quantitative MRI to comprehensively map hippocampal microstructure in healthy older adults with first-degree family history of Alzheimer’s disease and correlate maps with demographic risk factors for Alzheimer's disease. Results: We identified two key contributors of microstructural variation (myelin content and free water). We revealed localized age-related demyelination and sex differences in hippocampal proton density. Impact: This research provides crucial insights into age-related hippocampal microstructural changes and their implications for Alzheimer's disease. It has the potential to advance early detection and intervention strategies, ultimately improving patient outcomes in Alzheimer's disease management.