Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood

Journal article

G. R. Turner, Patrick A Hewan, Alfie Wearn, Roel van Dooren, Lindsay Wyatt, Ilana R Leppert, Giulia Baracchini, Colleen Hughes, Kayla Williams, Elisabeth Sylvain, J. Tremblay-Mercier, Judes Poirier, Sylvia Villeneuve, C. Tardif, R. N. Spreng, G. Aumont‐Rodrigue, Mohamed Badawy, Sylvain Baillet, Julie Bailly, A. Baril, Véronique Bohbot, Lianne Boisvert, J. Breitner, Mallar M. Chakravarty, Louis Collins, Nolan-Patrick Cunningham, Mahsa Dadar, Samir Das, Marina Dauar-Tedeschi, Christine Déry, Simon Ducharme, Marie Josée Élie, Alan Evans, Alfonso Fajardo Valdez, Vladimir S Fonov, Jonathan Gallago, M. Geddes, Rick Hoge, Louise Hudon, Yasser Ituria-Medina, Mohammadali Javanray, Gabriel Jean, A. Labonté, Marc Lalancette, L. Munter, Laurence Maligne Bruneau, Julien Menes, Béry Mohammediyan, Gerhard Multhaup, Eugenia Nita Capota, Valentin Ourry, C. Picard, Judes Poirier, Ting Qiu, M. Quesnel, Natasha Rajah, Jean-Michel Raoult, Jordana Remz, P. Rosa-Neto, Jean-Paul Soucy, R. N. Spreng, Frédéric St-Onge, Elisabeth Sylvain, C. Tardif, J. Tremblay-Mercier, S. Tullo, Étienne Vachon-Presseau, Sylvia Villeneuve, Yara Yakoub
Proceedings of the National Academy of Sciences of the United States of America, 2024

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Turner, G. R., Hewan, P. A., Wearn, A., van Dooren, R., Wyatt, L., Leppert, I. R., … Yakoub, Y. (2024). Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood. Proceedings of the National Academy of Sciences of the United States of America.

Chicago/Turabian Click to copy
Turner, G. R., Patrick A Hewan, Alfie Wearn, Roel van Dooren, Lindsay Wyatt, Ilana R Leppert, Giulia Baracchini, et al. “Locus Coeruleus Integrity Is Related to an Exploitation-Based Decision-Making Bias in Older Adulthood.” Proceedings of the National Academy of Sciences of the United States of America (2024).

MLA Click to copy
Turner, G. R., et al. “Locus Coeruleus Integrity Is Related to an Exploitation-Based Decision-Making Bias in Older Adulthood.” Proceedings of the National Academy of Sciences of the United States of America, 2024.

BibTeX Click to copy

@article{g2024a,
  title = {Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood},
  year = {2024},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  author = {Turner, G. R. and Hewan, Patrick A and Wearn, Alfie and van Dooren, Roel and Wyatt, Lindsay and Leppert, Ilana R and Baracchini, Giulia and Hughes, Colleen and Williams, Kayla and Sylvain, Elisabeth and Tremblay-Mercier, J. and Poirier, Judes and Villeneuve, Sylvia and Tardif, C. and Spreng, R. N. and Aumont‐Rodrigue, G. and Badawy, Mohamed and Baillet, Sylvain and Bailly, Julie and Baril, A. and Bohbot, Véronique and Boisvert, Lianne and Breitner, J. and Chakravarty, Mallar M. and Collins, Louis and Cunningham, Nolan-Patrick and Dadar, Mahsa and Das, Samir and Dauar-Tedeschi, Marina and Déry, Christine and Ducharme, Simon and Élie, Marie Josée and Evans, Alan and Valdez, Alfonso Fajardo and Fonov, Vladimir S and Gallago, Jonathan and Geddes, M. and Hoge, Rick and Hudon, Louise and Ituria-Medina, Yasser and Javanray, Mohammadali and Jean, Gabriel and Labonté, A. and Lalancette, Marc and Munter, L. and Bruneau, Laurence Maligne and Menes, Julien and Mohammediyan, Béry and Multhaup, Gerhard and Capota, Eugenia Nita and Ourry, Valentin and Picard, C. and Poirier, Judes and Qiu, Ting and Quesnel, M. and Rajah, Natasha and Raoult, Jean-Michel and Remz, Jordana and Rosa-Neto, P. and Soucy, Jean-Paul and Spreng, R. N. and St-Onge, Frédéric and Sylvain, Elisabeth and Tardif, C. and Tremblay-Mercier, J. and Tullo, S. and Vachon-Presseau, Étienne and Villeneuve, Sylvia and Yakoub, Yara}
}

Abstract

Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in older adulthood would be associated with lower microstructural integrity of the locus coeruleus. Leveraging in vivo histological methods from quantitative MRI-magnetic transfer saturation—we provide evidence that older age is associated with lower locus coeruleus integrity. Critically, we demonstrate that an exploitation bias in older adulthood, assessed with a foraging task, is sensitive and specific to lower locus coeruleus integrity. Because the locus coeruleus is uniquely vulnerable to Alzheimer’s disease pathology, our findings suggest that aging, and a presymptomatic trajectory of Alzheimer’s related decline, may fundamentally alter decision-making abilities in later life.